In the contemporary era, quantum mechanics is regarded as a foundational framework for both physics and metaphysics. Its application in the interpretation of the Holy Qur’an has attracted the attention of various scholars and thinkers. This study aims to clarify the scope and conditions under which quantum mechanics may influence Qur’anic interpretation. Data were collected through a library-based method and analyzed using a descriptive-analytical approach. A key condition for employing sciences such as quantum mechanics in Qur’anic interpretation is the certainty of the scientific principles involved. Given the philosophical challenges surrounding causality and realism, this paper critically evaluates the alleged contradictions between quantum mechanical assumptions and these two doctrines. The study shows that while quantum mechanics does not affirm deterministic causality in the classical sense and recognizes variability in causal conditions at the subatomic level, it still affirms causality in a general sense. Similarly, it demonstrates that quantum mechanics is not inherently contradictory to the existence of physical reality, supporting its compatibility with realism. Finally, the study outlines the following essential conditions for the effective influence of quantum mechanics on Qur’anic interpretation:1.A comprehensive understanding of Qur’anic vocabulary and the intended meanings of verses; 2. Examination of relevant Hadiths and scholarly opinions; 3. Identification of verse referents based on reliable scientific sources; 4. Comparative analysis of scientific findings and corresponding interpretations, with conclusive evidence supporting or refuting their compatibility; 5. Use of empirical sciences to better comprehend divine referents, while avoiding the imposition of hypotheses or theories onto the text; 6. Reliance on well-established propositions in quantum mechanics; 7. Clear distinction between hypotheses, theories, and technological application